IDS

Across TCGA patient cohorts, IDS mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IDS-associated genes across cancer lineages are eIF4E, Cyclin-E1, and GAPDH. Each is linked with IDS in more than 2 cancer types. Because this analysis shows association rather than direction, both IDS-to-partner and partner-to-IDS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by IDS-low versus IDS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDS→partner) and Y-score (partner→IDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.170	+2.321	.006	<.001	3	3
BRCA	Cyclin-E1 →	+0.443	+2.812	.008	.037	3	2
BRCA	GAPDH →	+1.034	+3.169	.001	.020	2	3
UCEC	eEF2 →	+0.269	+1.678	.010	.021	3	2
UCEC	Ku80 →	+0.241	+1.446	<.001	.003	3	2
UCEC	Notch1 →	+0.114	+2.100	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

eIF4E by IDS expression — UCEC

Explore this box plot interactively →