IDS

Across TCGA cell cohorts, IDS RNA expression is significantly associated with the go_rna of many other GO terms, with 5,102 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible IDS-associated GO terms across cancer lineages are Dermatan sulfate proteoglycan catabolic process, Amino acid metabolic process, and Regulation of post-translational protein modification. Each is linked with IDS in more than 18 cancer types. Because this analysis shows association rather than direction, both IDS-to-partner and partner-to-IDS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Dermatan sulfate proteoglycan catabolic process grouped by IDS-low versus IDS-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IDS→partner) and Y-score (partner→IDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Dermatan sulfate proteoglycan catabolic process →	+0.249	+1.395	<.001	<.001	3	19
SOFT_TISSUE	Amino acid metabolic process →	-0.078	-1.429	<.001	<.001	3	15
LARGE_INTESTINE	Regulation of post-translational protein modification →	+0.059	+1.580	<.001	<.001	3	15
LIVER	Dephosphorylation →	+0.065	+2.322	.001	<.001	3	15
LIVER	Regulation of stress-activated protein kinase signaling cascade →	+0.136	+2.502	.002	<.001	3	14
STOMACH	Endosomal transport →	+0.056	+1.349	.004	.002	1	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,102 associations by consensus.

Dermatan sulfate proteoglycan catabolic process by IDS expression — URINARY_TRACT

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