IDS

Across TCGA cell cohorts, IDS mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IDS-associated genes across cancer lineages are OXT, C5orf52, and UBTFL1. Each is linked with IDS in more than 1 cancer types. Because this analysis shows association rather than direction, both IDS-to-partner and partner-to-IDS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OXT grouped by IDS-low versus IDS-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDS→partner) and Y-score (partner→IDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OXT →	+0.070	+4.977	<.001	.007	3	1
SKIN	C5orf52 →	+0.062	+5.415	<.001	.004	3	1
OVARY	UBTFL1 →	+0.117	+4.807	<.001	.003	3	1
OVARY	OR2L8 →	+0.041	+4.450	<.001	.004	3	1
LARGE_INTESTINE	UTF1 →	+0.025	+4.217	<.001	.001	3	1
LARGE_INTESTINE	HNRNPCL4 →	+0.067	+3.793	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OXT by IDS expression — SKIN

Explore this box plot interactively →