IDO1

Across TCGA patient cohorts, IDO1 mutation is significantly associated with the RNA expression of many other genes, with 2,504 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IDO1-associated genes across cancer lineages are RNA5SP155, ARL2BPP4, and RNA5SP288. Each is linked with IDO1 in more than 2 cancer types. Because this analysis shows association rather than direction, both IDO1-to-partner and partner-to-IDO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP155 grouped by IDO1-low versus IDO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDO1→partner) and Y-score (partner→IDO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP155 →	+0.339	+1.729	.009	.005	3	3
LIHC	ARL2BPP4 →	+0.171	+6.008	<.001	.002	3	2
LIHC	RNA5SP288 →	+0.411	+5.033	<.001	.009	3	2
UCEC	FCER1A →	-0.868	-2.662	<.001	<.001	3	2
UCEC	ACTG1 →	+0.601	+2.684	<.001	<.001	3	2
UCEC	RPL23AP82 →	+0.400	+2.180	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,504 associations by consensus.

RNA5SP155 by IDO1 expression — UCEC

Explore this box plot interactively →