IDNK

Across TCGA pan-cancer cohorts, IDNK mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IDNK data layer compared with 29 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher IDNK mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated IDNK expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where IDNK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.888	0.644	.002	38	view →
CCRCC	OS	Median	All	1.000	0.888	.003	29	view →
HNSC	DFS	Median	III,IV	0.894	0.680	.010	12	view →
LUAD	DFS	Median	III,IV	0.263	0.744	.009	9	view →
LSCC	DFS	Quartile	II,III,IV	0.695	0.965	.032	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

IDNK–PDAC (DFS)

Open the PDAC breakdown →