IDNK

Across TCGA pan-cancer cohorts, IDNK RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of IDNK’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where IDNK RNA is repressed in tumor relative to normal tissue. In most cancer types IDNK is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and THCA are the cancer types where IDNK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IDNK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−2.941	<.001	11	view →
KIRP	All	III,IV	−1.727	<.001	11	view →
THCA	Male	IV	−1.286	<.001	11	view →
KIRC	Male	All	−1.069	<.001	11	view →
BLCA	Male	IV	−1.737	<.001	10	view →
LUSC	Male	III,IV	−1.694	<.001	8	view →
LIHC	Female	All	−1.079	<.001	8	view →
LUAD	Female	II,III,IV	−0.938	<.001	7	view →
COAD	Female	All	−0.658	.011	4	view →
BRCA	Female	II,III,IV	−0.361	<.001	4	view →
CHOL	All	All	−1.449	<.001	3	view →
HNSC	All	All	−0.286	.021	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

IDNK–KICH

Open the KICH breakdown →