IDI1

Across TCGA patient cohorts, IDI1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IDI1-associated genes across cancer lineages are 14-3-3_beta, FoxM1, and JNK_pT183_Y185. Each is linked with IDI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IDI1-to-partner and partner-to-IDI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by IDI1-low versus IDI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDI1→partner) and Y-score (partner→IDI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.110	-3.295	.010	.009	3	1
UCEC	FoxM1 →	+0.217	+2.222	.048	.011	3	1
UCEC	JNK_pT183_Y185 →	-0.187	-3.321	.008	.010	3	1
UCEC	JNK2 →	+0.166	+2.834	.048	.034	3	1
UCEC	Notch1 →	+0.140	+1.700	.019	.044	3	1
UCEC	p27_pT157 →	-0.052	-2.282	.034	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

14-3-3_beta by IDI1 expression — UCEC

Explore this box plot interactively →