IDH3G

Across TCGA pan-cancer cohorts, IDH3G mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IDH3G data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher IDH3G mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IDH3G expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where IDH3G mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	II,III,IV	0.407	0.844	.008	17	view →
PDAC	OS	Tertile	All	0.561	0.315	.013	12	view →
LSCC	DFS	Tertile	III,IV	0.804	1.000	.032	9	view →
GBM	DFS	Tertile	All	0.873	0.654	.018	4	view →
HNSC	OS	Median	All	0.956	1.000	.014	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

IDH3G–CCRCC (DFS)

Open the CCRCC breakdown →