IDH3G

Across TCGA pan-cancer cohorts, IDH3G RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of IDH3G’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IDH3G RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IDH3G is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

COAD, LIHC, and HNSC are the cancer types where IDH3G tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IDH3G RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	+0.635	<.001	10	view →
LIHC	Female	II,III,IV	+1.218	<.001	9	view →
HNSC	All	All	+0.392	<.001	8	view →
KICH	Female	II,III,IV	−0.581	<.001	7	view →
LUAD	Female	II,III,IV	+0.405	<.001	7	view →
CHOL	All	All	+1.747	<.001	5	view →
STAD	All	II,III,IV	+0.612	<.001	5	view →
LUSC	Male	All	+0.355	<.001	4	view →
KIRC	Male	II,III,IV	−0.317	.021	4	view →
THCA	Male	III,IV	−0.289	.004	3	view →
KIRP	Male	All	−0.204	.010	3	view →
ESCA	All	All	+0.688	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

IDH3G–COAD

Open the COAD breakdown →