IDH3G

Across TCGA patient cohorts, IDH3G mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IDH3G-associated genes across cancer lineages are EGFR_pY1068, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with IDH3G in more than 1 cancer types. Because this analysis shows association rather than direction, both IDH3G-to-partner and partner-to-IDH3G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by IDH3G-low versus IDH3G-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDH3G→partner) and Y-score (partner→IDH3G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.228	-2.700	.011	.006	3	2
UCEC	Caspase-7-cleavedD198 →	+0.673	+1.720	.001	.025	3	2
UCEC	14-3-3_beta →	-0.071	-2.432	.049	.018	3	1
UCEC	eEF2 →	+0.367	+1.584	.004	.019	3	1
UCEC	A-Raf_pS299 →	-0.110	-3.459	.010	.005	3	1
UCEC	mTOR_pS2448 →	-0.134	-2.095	.012	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

EGFR_pY1068 by IDH3G expression — UCEC

Explore this box plot interactively →