IDH3G

Across TCGA cell cohorts, IDH3G mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IDH3G-associated genes across cancer lineages are PRG3, P2RY12, and LCE1F. Each is linked with IDH3G in more than 1 cancer types. Because this analysis shows association rather than direction, both IDH3G-to-partner and partner-to-IDH3G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRG3 grouped by IDH3G-low versus IDH3G-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDH3G→partner) and Y-score (partner→IDH3G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRG3 →	+0.021	+4.415	<.001	.007	3	1
LARGE_INTESTINE	P2RY12 →	+0.114	+4.273	.009	.006	3	1
LARGE_INTESTINE	LCE1F →	+0.122	+4.415	<.001	.007	3	1
LARGE_INTESTINE	C1orf232 →	+0.024	+4.415	<.001	.007	3	1
BLOOD_Leukemia	ELMOD1 →	+0.174	+3.557	<.001	.005	3	1
BLOOD_Leukemia	TTLL2 →	+0.394	+3.540	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

PRG3 by IDH3G expression — LARGE_INTESTINE

Explore this box plot interactively →