IDH3B

Across TCGA patient cohorts, IDH3B mutation is significantly associated with the RNA expression of many other genes, with 363 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IDH3B-associated genes across cancer lineages are MIR194-1, RFKP1, and RNA5SP21. Each is linked with IDH3B in more than 1 cancer types. Because this analysis shows association rather than direction, both IDH3B-to-partner and partner-to-IDH3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR194-1 grouped by IDH3B-low versus IDH3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDH3B→partner) and Y-score (partner→IDH3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR194-1 →	+0.682	+2.957	<.001	<.001	3	2
UCEC	RFKP1 →	+0.112	+2.782	<.001	.004	3	2
UCEC	RNA5SP21 →	+0.718	+2.359	.002	.004	3	2
UCEC	EIF3JP1 →	+0.213	+2.520	<.001	.002	3	2
BLCA	TMSB4XP3 →	+0.513	+4.241	<.001	.003	3	2
UCEC	NEK7 →	+0.767	+3.212	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 363 associations by consensus.

MIR194-1 by IDH3B expression — UCEC

Explore this box plot interactively →