IDH3B

Across TCGA pan-cancer cohorts, IDH3B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of IDH3B’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where IDH3B RNA is repressed in tumor relative to normal tissue. In most cancer types IDH3B is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, STAD, and LIHC are the cancer types where IDH3B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IDH3B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	−0.370	<.001	10	view →
STAD	Male	II,III,IV	+0.739	<.001	9	view →
LIHC	Female	II,III,IV	+1.172	<.001	8	view →
KIRC	Female	All	+0.371	<.001	8	view →
HNSC	All	III,IV	+0.368	.002	8	view →
LUSC	Male	All	+0.689	<.001	7	view →
CHOL	All	All	+1.676	<.001	5	view →
COAD	Female	All	+0.590	.001	4	view →
KICH	All	All	−0.319	.008	3	view →
LUAD	All	IV	+0.384	.025	2	view →
PRAD	All	All	−0.193	.020	2	view →
ESCA	All	All	+0.418	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

IDH3B–THCA

Open the THCA breakdown →