IDH3B

Across TCGA patient cohorts, IDH3B mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IDH3B-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and Rictor_pT1135. Each is linked with IDH3B in more than 1 cancer types. Because this analysis shows association rather than direction, both IDH3B-to-partner and partner-to-IDH3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by IDH3B-low versus IDH3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDH3B→partner) and Y-score (partner→IDH3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.130	-2.973	.005	.035	3	1
UCEC	eIF4E →	+0.200	+3.700	.042	.001	3	1
UCEC	Rictor_pT1135 →	-0.127	-3.321	.008	.010	3	1
UCEC	Di-Ras3 →	-0.156	-3.156	.023	.018	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

14-3-3_beta by IDH3B expression — UCEC

Explore this box plot interactively →