IDH2-DT

Across TCGA pan-cancer cohorts, IDH2-DT RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated IDH2-DT data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher IDH2-DT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IDH2-DT expression acts as an unfavorable survival marker, although some lineages such as HNSC and ESCA show a favorable association.

ACC, HNSC, and BLCA are the cancer types where IDH2-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.771	0.891	.005	42	view →
HNSC	DFS	Tertile	All	0.675	0.455	.005	31	view →
BLCA	DFS	Quartile	All	0.542	0.676	.002	30	view →
KIRC	DFS	Median	All	0.550	0.682	.010	28	view →
CHOL	OS	Quartile	II,III,IV	0.175	0.875	.001	27	view →
ESCA	OS	Median	III,IV	0.689	0.438	.007	24	view →
LGG	DFS	Quartile	All	0.533	0.298	.001	20	view →
UCEC	DFS	Quartile	All	0.862	0.923	.010	20	view →
SKCM	DFS	Tertile	IV	0.051	0.501	.003	18	view →
LAML	DFS	Quartile	All	0.687	0.358	.011	10	view →
MESO	OS	Tertile	IV	0.437	0.619	.048	9	view →
STAD	DFS	Median	All	0.614	0.494	.023	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

IDH2-DT–ACC (OS)

Open the ACC breakdown →