IDH2-DT

Across TCGA pan-cancer cohorts, IDH2-DT RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of IDH2-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where IDH2-DT RNA is repressed in tumor relative to normal tissue. In most cancer types IDH2-DT is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and HNSC are the cancer types where IDH2-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IDH2-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−2.127	<.001	12	view →
KIRP	Male	All	−2.153	<.001	11	view →
HNSC	Male	All	−0.713	<.001	8	view →
THCA	All	All	−0.203	<.001	7	view →
BRCA	All	All	+0.382	<.001	4	view →
LUSC	Male	All	+0.175	.001	4	view →
UCEC	All	IV	+0.644	.003	2	view →
LUAD	All	All	+0.225	.004	2	view →
STAD	Male	IV	−1.175	.026	1	view →
ESCA	All	All	−0.980	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

IDH2-DT–KIRC

Open the KIRC breakdown →