IDH1-AS1

Across TCGA pan-cancer cohorts, IDH1-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated IDH1-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IDH1-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IDH1-AS1 expression acts as an unfavorable survival marker, although some lineages such as OV and BRCA show a favorable association.

HNSC, ACC, and LIHC are the cancer types where IDH1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.285	0.486	<.001	73	view →
ACC	DFS	Median	All	0.275	0.661	.001	42	view →
LIHC	OS	Median	All	0.712	0.835	.002	39	view →
KIRC	DFS	Tertile	IV	0.225	0.721	.003	38	view →
OV	DFS	Quartile	IV	0.621	0.341	.025	30	view →
THYM	DFS	Quartile	III,IV	0.312	0.843	.008	27	view →
STAD	OS	Tertile	II,III,IV	0.556	0.780	.001	25	view →
KICH	OS	Quartile	III,IV	0.192	0.828	.010	16	view →
THCA	OS	Median	II,III,IV	0.570	1.000	.008	16	view →
BRCA	OS	Quartile	All	0.974	0.943	.022	12	view →
ESCA	DFS	Tertile	All	0.404	0.618	.006	10	view →
SKCM	OS	Tertile	II,III,IV	0.792	0.889	.009	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

IDH1-AS1–HNSC (DFS)

Open the HNSC breakdown →