IDH1-AS1

Across TCGA pan-cancer cohorts, IDH1-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of IDH1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where IDH1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types IDH1-AS1 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, LIHC, and LUAD are the cancer types where IDH1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IDH1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.285	<.001	10	view →
LIHC	Male	II,III,IV	+1.159	<.001	8	view →
LUAD	All	All	+0.464	<.001	7	view →
UCEC	All	All	+0.847	<.001	6	view →
BLCA	Female	All	+0.778	.010	5	view →
KIRP	All	II,III,IV	+0.551	.004	5	view →
KIRC	All	All	−0.248	<.001	4	view →
LUSC	All	All	+0.398	.001	3	view →
HNSC	Male	III,IV	+0.398	.038	2	view →
PRAD	All	All	+0.380	.010	2	view →
STAD	Male	III,IV	+0.518	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

IDH1-AS1–KICH

Open the KICH breakdown →