IDE

Across TCGA patient cohorts, IDE mutation is significantly associated with the RNA expression of many other genes, with 2,982 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IDE-associated genes across cancer lineages are MRPS33P3, OR4C45, and TUBBP3. Each is linked with IDE in more than 2 cancer types. Because this analysis shows association rather than direction, both IDE-to-partner and partner-to-IDE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS33P3 grouped by IDE-low versus IDE-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDE→partner) and Y-score (partner→IDE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MRPS33P3 →	+0.056	+2.927	.001	.003	3	3
HNSC	OR4C45 →	+0.048	+6.608	<.001	.001	3	3
LIHC	TUBBP3 →	+0.037	+4.758	<.001	.006	3	2
UCEC	ZNHIT3 →	+0.419	+3.775	.001	<.001	3	2
UCEC	TAF9 →	+0.547	+4.021	<.001	<.001	3	2
UCEC	FRG1HP →	+0.486	+2.491	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,982 associations by consensus.

MRPS33P3 by IDE expression — SKCM

Explore this box plot interactively →