IDE

Across TCGA pan-cancer cohorts, IDE RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of IDE’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where IDE RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IDE is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

LIHC, LUAD, and BRCA are the cancer types where IDE tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IDE RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+0.989	<.001	9	view →
LUAD	Male	II,III,IV	+1.006	<.001	8	view →
BRCA	All	II,III,IV	+0.632	<.001	8	view →
LUSC	Female	All	+0.575	<.001	7	view →
KICH	Female	II,III,IV	−1.042	<.001	6	view →
CHOL	All	All	+1.380	<.001	5	view →
KIRP	All	II,III,IV	+0.533	.006	5	view →
UCEC	All	III,IV	+0.896	.016	4	view →
STAD	All	II,III,IV	+0.517	.021	4	view →
COAD	Male	All	+0.476	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

IDE–LIHC

Open the LIHC breakdown →