IDE

Across TCGA patient cohorts, IDE mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IDE-associated genes across cancer lineages are FoxM1, Ku80, and mTOR_pS2448. Each is linked with IDE in more than 1 cancer types. Because this analysis shows association rather than direction, both IDE-to-partner and partner-to-IDE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by IDE-low versus IDE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDE→partner) and Y-score (partner→IDE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.206	+1.415	.033	.046	3	2
UCEC	Ku80 →	+0.185	+1.428	.037	.029	3	2
UCEC	mTOR_pS2448 →	-0.131	-2.095	.019	.017	3	2
UCEC	Notch1 →	+0.143	+1.594	.006	.042	3	2
UCEC	ASNS →	+0.525	+3.584	<.001	.002	3	2
UCEC	14-3-3_beta →	-0.103	-2.432	.006	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

FoxM1 by IDE expression — UCEC

Explore this box plot interactively →