IDE

Across TCGA cell cohorts, IDE mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IDE-associated genes across cancer lineages are REG3A, TCF21, and SFT2D3. Each is linked with IDE in more than 1 cancer types. Because this analysis shows association rather than direction, both IDE-to-partner and partner-to-IDE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG3A grouped by IDE-low versus IDE-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDE→partner) and Y-score (partner→IDE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	REG3A →	+0.073	+4.584	<.001	.002	3	1
BLOOD_Leukemia	TCF21 →	+0.008	+3.705	.002	.007	3	1
BLOOD_Leukemia	SFT2D3 →	+0.699	+4.450	<.001	.001	3	1
BLOOD_Leukemia	TAS1R2 →	+0.015	+3.855	<.001	.007	3	1
BLOOD_Leukemia	USP17L8 →	+0.003	+4.384	<.001	.006	3	1
SKIN	SULT6B1 →	+0.123	+3.920	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

REG3A by IDE expression — URINARY_TRACT

Explore this box plot interactively →