IDE

Across TCGA cell cohorts, IDE mutation is significantly associated with the mutation status of many other genes, with 4,808 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IDE-associated genes across cancer lineages are ADCY5, KLHL29, and SLTM. Each is linked with IDE in more than 5 cancer types. Because this analysis shows association rather than direction, both IDE-to-partner and partner-to-IDE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADCY5 grouped by IDE-low versus IDE-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDE→partner) and Y-score (partner→IDE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ADCY5 →	+4.392	+4.954	.008	.008	1	6
SKIN	KLHL29 →	+4.187	+4.532	<.001	<.001	1	5
CNS	SLTM →	+4.614	+4.614	.006	.006	1	5
LARGE_INTESTINE	KDM3B →	+2.444	+3.614	<.001	<.001	1	5
UPPER_AERODIGESTIVE_TRACT	HECW2 →	+4.392	+4.954	.008	.008	1	5
LARGE_INTESTINE	GRIK3 →	+2.347	+4.479	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,808 associations by consensus.

ADCY5 by IDE expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →