ID2-AS1

Across TCGA pan-cancer cohorts, ID2-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ID2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ID2-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types ID2-AS1 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, COAD, and BLCA are the cancer types where ID2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ID2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.407	<.001	11	view →
COAD	Female	III,IV	−1.017	<.001	9	view →
BLCA	Male	III,IV	−0.932	.005	8	view →
BRCA	All	III,IV	−0.361	<.001	6	view →
THCA	All	All	−0.328	<.001	6	view →
KIRC	All	III,IV	+0.250	.012	6	view →
LUAD	Female	II,III,IV	−0.310	<.001	5	view →
READ	Female	All	−0.936	.002	2	view →
UCEC	All	IV	−0.710	.043	2	view →
PRAD	All	All	−0.504	<.001	2	view →
HNSC	All	IV	+0.186	.030	2	view →
KIRP	Female	All	+0.962	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ID2-AS1–KICH

Open the KICH breakdown →