ICAM5

Across TCGA patient cohorts, ICAM5 mutation is significantly associated with the RNA expression of many other genes, with 426 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ICAM5-associated genes across cancer lineages are TRDV3, NANOGP3, and RNU6-1045P. Each is linked with ICAM5 in more than 2 cancer types. Because this analysis shows association rather than direction, both ICAM5-to-partner and partner-to-ICAM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRDV3 grouped by ICAM5-low versus ICAM5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICAM5→partner) and Y-score (partner→ICAM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRDV3 →	+0.300	+2.176	<.001	.003	3	3
LIHC	NANOGP3 →	+0.167	+4.105	<.001	.001	3	2
CESC	RNU6-1045P →	+0.346	+4.349	<.001	<.001	3	2
LGG	RN7SL759P →	+0.129	+7.977	<.001	.007	3	2
SKCM	RNU5A-4P →	+0.427	+4.084	<.001	<.001	3	2
SKCM	BCAR1P2 →	+0.066	+3.595	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 426 associations by consensus.

TRDV3 by ICAM5 expression — UCEC

Explore this box plot interactively →