ICAM5

Across TCGA pan-cancer cohorts, ICAM5 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ICAM5’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ICAM5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ICAM5 is over-expressed in tumor, although a few such as LUAD and BRCA show the opposite, repressed pattern.

HNSC, THCA, and KICH are the cancer types where ICAM5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ICAM5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.386	<.001	12	view →
THCA	All	IV	+3.132	<.001	11	view →
KICH	All	II,III,IV	+1.613	<.001	9	view →
COAD	All	IV	+0.488	.001	9	view →
LUAD	Male	II,III,IV	−1.877	<.001	8	view →
BLCA	Male	III,IV	+0.777	.011	6	view →
BRCA	All	III,IV	−0.654	<.001	6	view →
KIRC	All	II,III,IV	−0.284	<.001	6	view →
LIHC	All	All	+0.240	<.001	6	view →
LUSC	Female	All	−1.840	<.001	5	view →
STAD	All	All	+0.432	.003	5	view →
KIRP	Male	All	−0.237	.003	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ICAM5–HNSC

Open the HNSC breakdown →