ICAM5

Across TCGA patient cohorts, ICAM5 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ICAM5-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and eIF4E. Each is linked with ICAM5 in more than 3 cancer types. Because this analysis shows association rather than direction, both ICAM5-to-partner and partner-to-ICAM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ICAM5-low versus ICAM5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICAM5→partner) and Y-score (partner→ICAM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.327	+2.999	.003	.035	3	2
COAD	Caspase-7-cleavedD198 →	+1.563	+2.815	<.001	.036	1	4
UCEC	eIF4E →	+0.237	+3.000	.032	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.197	-3.308	.025	.010	3	1
UCEC	Myosin-IIa_pS1943 →	+0.237	+2.183	.028	.035	3	1
UCEC	Cyclin-B1 →	+0.751	+3.169	.010	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PCNA by ICAM5 expression — UCEC

Explore this box plot interactively →