ICAM2

Across TCGA cell cohorts, ICAM2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ICAM2-associated genes across cancer lineages are HSFY2, OR10W1, and EPPIN. Each is linked with ICAM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ICAM2-to-partner and partner-to-ICAM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSFY2 grouped by ICAM2-low versus ICAM2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICAM2→partner) and Y-score (partner→ICAM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HSFY2 →	+0.023	+4.977	<.001	.007	3	1
LARGE_INTESTINE	OR10W1 →	+0.012	+4.977	.002	.007	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	AMELX →	+0.031	+5.539	<.001	.003	3	1
BLOOD_Leukemia	OR3A1 →	+1.055	+4.922	<.001	.009	3	1
BLOOD_Leukemia	FIGLA →	+0.036	+6.569	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

HSFY2 by ICAM2 expression — LARGE_INTESTINE

Explore this box plot interactively →