ICAM1

Across TCGA patient cohorts, ICAM1 mutation is significantly associated with the RNA expression of many other genes, with 2,170 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ICAM1-associated genes across cancer lineages are DEFB129, OR9G1, and VWA8P1. Each is linked with ICAM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ICAM1-to-partner and partner-to-ICAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB129 grouped by ICAM1-low versus ICAM1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICAM1→partner) and Y-score (partner→ICAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	DEFB129 →	+0.352	+5.517	<.001	.001	3	3
LUSC	OR9G1 →	+0.366	+4.853	<.001	.004	3	3
LUSC	VWA8P1 →	+0.329	+5.321	<.001	.002	3	3
COAD	MTND3P13 →	+0.189	+4.308	<.001	.009	3	3
LIHC	RNU6-314P →	+0.384	+5.647	<.001	.004	3	3
SKCM	LINC01817 →	+0.079	+4.884	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,170 associations by consensus.

DEFB129 by ICAM1 expression — LUSC

Explore this box plot interactively →