ICAM1

Across TCGA pan-cancer cohorts, ICAM1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ICAM1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ICAM1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ICAM1 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

THCA, KIRC, and HNSC are the cancer types where ICAM1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ICAM1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	+2.655	<.001	11	view →
KIRC	Male	IV	+2.005	<.001	11	view →
HNSC	Female	III,IV	+1.902	<.001	11	view →
COAD	All	III,IV	+1.083	<.001	10	view →
KICH	Female	II,III,IV	−2.598	<.001	9	view →
LUSC	All	II,III,IV	−2.678	<.001	8	view →
STAD	Male	II,III,IV	+1.853	<.001	8	view →
LUAD	Male	All	−1.410	<.001	5	view →
BRCA	All	All	+0.351	.007	4	view →
ESCA	All	All	+2.022	<.001	3	view →
CHOL	All	All	+1.948	.017	1	view →
KIRP	All	All	+0.490	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ICAM1–THCA

Open the THCA breakdown →