ICAM1

Across TCGA cell cohorts, ICAM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,049 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible ICAM1-associated GO terms across cancer lineages are Receptor-mediated virion attachment to host cell, Complement-mediated synapse pruning, and Vertebrate eye-specific patterning. Each is linked with ICAM1 in more than 14 cancer types. Because this analysis shows association rather than direction, both ICAM1-to-partner and partner-to-ICAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Receptor-mediated virion attachment to host cell grouped by ICAM1-low versus ICAM1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ICAM1→partner) and Y-score (partner→ICAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Receptor-mediated virion attachment to host cell →	+1.541	+1.900	<.001	.001	3	15
LARGE_INTESTINE	Complement-mediated synapse pruning →	+1.522	+2.354	<.001	<.001	3	14
OVARY	Vertebrate eye-specific patterning →	+1.451	+2.432	<.001	.003	3	14
BREAST	Biological process involved in symbiotic interaction →	+0.101	+2.621	<.001	<.001	3	13
BREAST	Negative regulation of immune response →	+0.086	+2.561	<.001	<.001	3	13
BREAST	Positive regulation of complement activation →	+1.713	+2.227	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,049 associations by consensus.

Receptor-mediated virion attachment to host cell by ICAM1 expression — BONE

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