ICAM1

Across TCGA cell cohorts, ICAM1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ICAM1-associated genes across cancer lineages are OR2V2, RS1, and P2RX3. Each is linked with ICAM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ICAM1-to-partner and partner-to-ICAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2V2 grouped by ICAM1-low versus ICAM1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICAM1→partner) and Y-score (partner→ICAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR2V2 →	+0.023	+4.169	<.001	.008	3	1
BLOOD_Leukemia	RS1 →	+0.083	+3.771	.007	.004	3	1
BLOOD_Leukemia	P2RX3 →	+0.040	+3.551	.008	.008	3	1
BLOOD_Leukemia	ASB17 →	+0.010	+4.569	<.001	.003	3	1
BLOOD_Leukemia	ODF1 →	+0.065	+4.266	<.001	.001	3	1
BLOOD_Leukemia	CNGB3 →	+0.114	+3.567	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

OR2V2 by ICAM1 expression — CNS

Explore this box plot interactively →