ICA1L

Across TCGA patient cohorts, ICA1L mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ICA1L-associated genes across cancer lineages are eEF2, NF-kB-p65_pS536, and PDCD4. Each is linked with ICA1L in more than 1 cancer types. Because this analysis shows association rather than direction, both ICA1L-to-partner and partner-to-ICA1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ICA1L-low versus ICA1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICA1L→partner) and Y-score (partner→ICA1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.408	+1.662	.001	.011	3	2
UCEC	NF-kB-p65_pS536 →	-0.409	-3.321	.010	.009	3	2
UCEC	PDCD4 →	-0.428	-1.700	.010	.040	3	2
UCEC	ERK2 →	+0.174	+1.906	.010	.015	3	1
UCEC	FOXO3a_pS318_S321 →	-0.160	-2.999	<.001	<.001	3	1
UCEC	GAPDH →	+0.586	+2.392	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

eEF2 by ICA1L expression — UCEC

Explore this box plot interactively →