ICA1L

Across TCGA pan-cancer cohorts, ICA1L RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ICA1L data layer compared with 2 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher ICA1L RNA is associated with better overall survival. In most high-consensus cancer types, elevated ICA1L expression acts as an unfavorable survival marker, although some lineages such as BLCA and BRCA show a favorable association.

BLCA, BRCA, and PAAD are the cancer types where ICA1L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	All	0.804	0.660	.004	60	view →
BRCA	OS	Median	III,IV	0.642	0.411	<.001	50	view →
PAAD	DFS	Quartile	All	0.449	0.162	<.001	39	view →
UVM	DFS	Tertile	III,IV	0.231	0.719	.014	29	view →
LUAD	OS	Median	II,III,IV	0.314	0.187	.001	23	view →
KICH	OS	Quartile	All	0.604	1.000	.008	16	view →
LGG	OS	Median	All	0.757	0.893	.003	15	view →
CHOL	DFS	Median	II,III,IV	0.121	0.626	.002	15	view →
UCEC	DFS	Median	IV	0.684	0.308	.024	14	view →
CESC	OS	Median	All	0.856	0.739	.006	14	view →
UCS	DFS	Tertile	III,IV	0.480	0.112	.016	12	view →
LIHC	OS	Median	III,IV	0.415	0.630	.019	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ICA1L–BLCA (OS)

Open the BLCA breakdown →