IBTK

Across TCGA pan-cancer cohorts, IBTK mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated IBTK data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher IBTK mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated IBTK expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CCRCC, HNSC, and UCEC are the cancer types where IBTK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.730	1.000	.023	18	view →
HNSC	DFS	Tertile	III,IV	0.539	0.811	.021	10	view →
UCEC	DFS	Tertile	All	0.961	0.796	.022	8	view →
LSCC	DFS	Quartile	III,IV	0.523	0.901	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

IBTK–CCRCC (OS)

Open the CCRCC breakdown →