IBTK

Across TCGA pan-cancer cohorts, IBTK RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of IBTK’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where IBTK RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IBTK is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

STAD, KICH, and THCA are the cancer types where IBTK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IBTK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	II,III,IV	+0.668	.001	8	view →
KICH	Female	II,III,IV	−1.488	<.001	7	view →
THCA	Male	II,III,IV	−0.802	<.001	7	view →
KIRP	Female	II,III,IV	+0.629	.003	4	view →
LUAD	All	All	+0.275	.004	4	view →
BRCA	All	II,III,IV	+0.262	.001	4	view →
CHOL	All	II,III,IV	+0.989	.040	2	view →
LIHC	Male	All	+0.498	.002	2	view →
UCEC	All	All	−0.470	.004	2	view →
LUAD	All	IV	−0.169	.015	2	view →
READ	Female	All	−0.583	.033	1	view →
BLCA	Male	IV	+0.259	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

IBTK–STAD

Open the STAD breakdown →