IBTK

Across TCGA patient cohorts, IBTK protein abundance is significantly associated with the RNA expression of many other genes, with 6,854 significant associations in total. COAD shows the largest number of these associations.

The most reproducible IBTK-associated genes across cancer lineages are PLAGL2, PGM3, and SPATA2. Each is linked with IBTK in more than 3 cancer types. Because this analysis shows association rather than direction, both IBTK-to-partner and partner-to-IBTK results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IBTK versus PLAGL2 in COAD, with a Pearson correlation of -0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IBTK→partner) and Y-score (partner→IBTK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PLAGL2 →	-0.855	-0.304	<.001	.001	3	4
UCEC	PGM3 →	+0.511	+0.205	<.001	<.001	3	4
HNSC	SPATA2 →	-0.508	-0.301	.001	.001	3	4
UCEC	SUCLG2 →	+0.547	+0.189	.001	<.001	3	3
COAD	RPS27L →	+0.686	+0.490	<.001	<.001	3	3
HNSC	SERPINA1 →	+1.089	+0.381	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,854 associations by consensus.

IBTK vs PLAGL2 — COAD

Explore this scatter interactively →