IBTK

Across TCGA patient cohorts, IBTK mutation is significantly associated with the RNA expression of many other genes, with 4,029 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IBTK-associated genes across cancer lineages are NCAPH2, TUBG1, and ACO2. Each is linked with IBTK in more than 3 cancer types. Because this analysis shows association rather than direction, both IBTK-to-partner and partner-to-IBTK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCAPH2 grouped by IBTK-low versus IBTK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IBTK→partner) and Y-score (partner→IBTK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCAPH2 →	+0.475	+1.925	<.001	<.001	3	4
UCEC	TUBG1 →	+0.565	+1.936	<.001	<.001	3	4
UCEC	ACO2 →	+0.668	+2.294	<.001	<.001	3	4
CESC	RNA5SP410 →	+0.470	+4.984	<.001	.003	3	3
CESC	RNA5SP417 →	+0.401	+5.252	<.001	.002	3	3
LUSC	HROB →	+0.545	+3.477	.007	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,029 associations by consensus.

NCAPH2 by IBTK expression — UCEC

Explore this box plot interactively →