IBTK

Across TCGA patient cohorts, IBTK mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IBTK-associated genes across cancer lineages are eIF4E, ASNS, and Caspase-7-cleavedD198. Each is linked with IBTK in more than 2 cancer types. Because this analysis shows association rather than direction, both IBTK-to-partner and partner-to-IBTK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by IBTK-low versus IBTK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IBTK→partner) and Y-score (partner→IBTK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.208	+1.736	<.001	<.001	3	3
UCEC	ASNS →	+0.291	+1.459	.005	.011	3	3
UCEC	Caspase-7-cleavedD198 →	+0.590	+1.736	<.001	.001	3	3
SKCM	S6_pS235_S236 →	+0.577	+3.459	.006	.005	3	2
SKCM	Di-Ras3 →	-0.170	-3.459	.015	.005	3	2
UCEC	EGFR →	-0.109	-1.584	.017	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

eIF4E by IBTK expression — UCEC

Explore this box plot interactively →