IBTK

Across TCGA cell cohorts, IBTK RNA expression is significantly associated with the go_rna of many other GO terms, with 2,769 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IBTK-associated GO terms across cancer lineages are Protein demannosylation, Protein alpha-1,2-demannosylation, and 7-methylguanosine mRNA capping. Each is linked with IBTK in more than 12 cancer types. Because this analysis shows association rather than direction, both IBTK-to-partner and partner-to-IBTK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein demannosylation grouped by IBTK-low versus IBTK-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IBTK→partner) and Y-score (partner→IBTK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Protein demannosylation →	+0.093	+0.700	.004	.001	2	13
BREAST	Protein alpha-1,2-demannosylation →	+0.093	+0.700	.004	.001	2	13
KIDNEY	7-methylguanosine mRNA capping →	+0.090	+0.533	.003	.005	3	11
KIDNEY	7-methylguanosine RNA capping →	+0.090	+0.533	.003	.005	3	11
CNS	Protein deglycosylation →	+0.076	+0.618	.004	<.001	3	10
SKIN	Regulation of formation of translation preinitiation complex →	+0.064	+0.355	<.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,769 associations by consensus.

Protein demannosylation by IBTK expression — BREAST

Explore this box plot interactively →