IBTK

Across TCGA cell cohorts, IBTK mutation is significantly associated with the RNA expression of many other genes, with 224 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IBTK-associated genes across cancer lineages are OR12D3, TOPAZ1, and ARGFX. Each is linked with IBTK in more than 1 cancer types. Because this analysis shows association rather than direction, both IBTK-to-partner and partner-to-IBTK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR12D3 grouped by IBTK-low versus IBTK-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IBTK→partner) and Y-score (partner→IBTK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR12D3 →	+0.056	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	TOPAZ1 →	+0.013	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	ARGFX →	+0.032	+5.662	<.001	.002	3	1
STOMACH	SKOR2 →	+0.023	+5.285	<.001	.003	3	1
STOMACH	PRAMEF4 →	+0.006	+5.285	<.001	.003	3	1
LARGE_INTESTINE	CPNE6 →	+0.311	+3.237	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 224 associations by consensus.

OR12D3 by IBTK expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →