IBSP

Across TCGA cell cohorts, IBSP RNA expression is significantly associated with the go_rna of many other GO terms, with 373 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible IBSP-associated GO terms across cancer lineages are Negative regulation of transforming growth factor beta production, Autophagosome organization, and Chloride transmembrane transport. Each is linked with IBSP in more than 3 cancer types. Because this analysis shows association rather than direction, both IBSP-to-partner and partner-to-IBSP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of transforming growth factor beta production grouped by IBSP-low versus IBSP-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IBSP→partner) and Y-score (partner→IBSP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Negative regulation of transforming growth factor beta production →	+0.185	+0.350	<.001	.003	3	4
STOMACH	Autophagosome organization →	+0.052	+0.333	.003	.008	3	4
UPPER_AERODIGESTIVE_TRACT	Chloride transmembrane transport →	-0.056	-0.112	.004	.001	3	4
UPPER_AERODIGESTIVE_TRACT	Calcium ion transport →	-0.037	-0.093	.007	.002	2	4
UPPER_AERODIGESTIVE_TRACT	Chloride transport →	-0.055	-0.099	.007	.004	2	4
LUNG_NSCLC_LUAD	Metanephric mesenchyme development →	+0.107	+0.404	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 373 associations by consensus.

Negative regulation of transforming growth factor beta production by IBSP expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →