IBSP

Across TCGA pan-cancer cohorts, IBSP RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of IBSP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IBSP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IBSP is over-expressed in tumor.

HNSC, COAD, and KIRC are the cancer types where IBSP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IBSP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.854	<.001	12	view →
COAD	Male	IV	+2.124	<.001	11	view →
KIRC	Female	III,IV	+1.609	<.001	11	view →
BLCA	All	III,IV	+1.102	<.001	10	view →
LUAD	Female	II,III,IV	+2.183	<.001	9	view →
THCA	Male	All	+0.569	<.001	8	view →
BRCA	All	III,IV	+2.420	<.001	6	view →
STAD	Male	II,III,IV	+1.678	<.001	6	view →
LUSC	Male	II,III,IV	+1.531	<.001	6	view →
UCEC	All	All	+0.820	.001	6	view →
KIRP	All	All	+0.567	.001	6	view →
LIHC	All	All	+0.477	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

IBSP–HNSC

Open the HNSC breakdown →