Across TCGA pan-cancer cohorts, IBA57-DT RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of IBA57-DT’s most consistent transcriptional readouts.
The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where IBA57-DT RNA is repressed in tumor relative to normal tissue. In most cancer types IBA57-DT is over-expressed in tumor, although a few such as UCEC and LUAD show the opposite, repressed pattern.
UCEC, HNSC, and LIHC are the cancer types where IBA57-DT tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IBA57-DT RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.