IARS2

Across TCGA patient cohorts, IARS2 protein abundance is significantly associated with the RNA expression of many other genes, with 19,130 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IARS2-associated genes across cancer lineages are MT-CO2, CYTH4, and CSF2RB. Each is linked with IARS2 in more than 7 cancer types. Because this analysis shows association rather than direction, both IARS2-to-partner and partner-to-IARS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IARS2 versus MT-CO2 in HNSC, with a Pearson correlation of 0.26.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IARS2→partner) and Y-score (partner→IARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MT-CO2 →	+0.997	+0.252	.002	<.001	3	8
HNSC	CYTH4 →	-0.951	-0.360	<.001	<.001	3	6
BRCA	CSF2RB →	-1.113	-0.444	.001	<.001	3	6
BRCA	EHD4 →	-0.381	-0.321	<.001	<.001	3	6
COAD	LILRB1 →	-0.926	-0.362	<.001	<.001	3	6
HNSC	SEMA7A →	-1.044	-0.335	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,130 associations by consensus.

IARS2 vs MT-CO2 — HNSC

Explore this scatter interactively →