IARS2

Across TCGA pan-cancer cohorts, IARS2 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of IARS2’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where IARS2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IARS2 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

LUAD, HNSC, and BLCA are the cancer types where IARS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IARS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	IV	+1.424	<.001	11	view →
HNSC	All	III,IV	+0.612	<.001	10	view →
BLCA	All	III,IV	+0.760	<.001	9	view →
LIHC	Male	II,III,IV	+1.182	<.001	8	view →
LUSC	Male	II,III,IV	+1.060	<.001	8	view →
STAD	Male	All	+0.881	<.001	6	view →
BRCA	All	III,IV	+0.723	<.001	6	view →
CHOL	All	All	+1.571	<.001	5	view →
KIRP	Female	II,III,IV	+0.855	.004	5	view →
KICH	All	All	−0.652	.001	4	view →
PAAD	All	All	+0.515	.029	2	view →
COAD	Male	All	+0.295	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

IARS2–LUAD

Open the LUAD breakdown →