IARS2

Across TCGA cell cohorts, IARS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,792 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible IARS2-associated GO terms across cancer lineages are Nuclear pore complex assembly, Nuclear pore organization, and Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery. Each is linked with IARS2 in more than 14 cancer types. Because this analysis shows association rather than direction, both IARS2-to-partner and partner-to-IARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear pore complex assembly grouped by IARS2-low versus IARS2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IARS2→partner) and Y-score (partner→IARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Nuclear pore complex assembly →	+0.170	+0.647	.004	.005	3	15
BONE	Nuclear pore organization →	+0.210	+0.869	<.001	.002	3	15
UPPER_AERODIGESTIVE_TRACT	Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.145	+0.997	<.001	.002	3	13
LUNG_NSCLC_LUSC	Tetrapyrrole biosynthetic process →	+0.124	+0.779	.006	.002	3	13
LUNG_NSCLC_LUSC	Porphyrin-containing compound biosynthetic process →	+0.124	+0.779	.006	.002	3	13
LUNG_NSCLC_LUSC	Heme biosynthetic process →	+0.109	+0.779	.007	.002	2	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,792 associations by consensus.

Nuclear pore complex assembly by IARS2 expression — BONE

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