IARS2

Across TCGA cell cohorts, IARS2 mutation is significantly associated with the RNA expression of many other genes, with 99 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IARS2-associated genes across cancer lineages are CD300H, CEACAM4, and TAAR8. Each is linked with IARS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IARS2-to-partner and partner-to-IARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD300H grouped by IARS2-low versus IARS2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IARS2→partner) and Y-score (partner→IARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CD300H →	+0.020	+3.000	<.001	.003	3	2
BLOOD_Myeloma	CEACAM4 →	+0.043	+4.807	<.001	.006	3	1
BLOOD_Myeloma	TAAR8 →	+0.020	+4.807	<.001	.006	3	1
BLOOD_Myeloma	CCKAR →	+0.006	+4.807	<.001	.006	3	1
BLOOD_Myeloma	GALR1 →	+0.013	+4.807	<.001	.006	3	1
BLOOD_Myeloma	MYL1 →	+0.433	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 99 associations by consensus.

CD300H by IARS2 expression — LARGE_INTESTINE

Explore this box plot interactively →