IARS2

Across TCGA cell cohorts, IARS2 mutation is significantly associated with the mutation status of many other genes, with 4,855 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IARS2-associated genes across cancer lineages are RC3H1, PKD1, and HDAC5. Each is linked with IARS2 in more than 3 cancer types. Because this analysis shows association rather than direction, both IARS2-to-partner and partner-to-IARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RC3H1 grouped by IARS2-low versus IARS2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IARS2→partner) and Y-score (partner→IARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RC3H1 →	+3.548	+2.830	.009	.009	1	4
LARGE_INTESTINE	PKD1 →	+1.058	+2.482	.009	.009	1	3
SKIN	HDAC5 →	+3.548	+2.830	.009	.009	1	3
LARGE_INTESTINE	SIM1 →	+2.544	+2.667	<.001	<.001	1	3
LARGE_INTESTINE	PARD3B →	+2.736	+3.050	<.001	<.001	1	3
LARGE_INTESTINE	RBM19 →	+3.058	+2.514	.002	.002	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,855 associations by consensus.

RC3H1 by IARS2 expression — SKIN

Explore this box plot interactively →