HYPK

Across TCGA pan-cancer cohorts, HYPK mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HYPK data layer compared with 22 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher HYPK mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HYPK expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, UCEC, and CCRCC are the cancer types where HYPK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	III,IV	0.892	0.429	.001	26	view →
UCEC	DFS	Tertile	II,III,IV	0.919	0.500	.027	20	view →
CCRCC	DFS	Tertile	IV	0.887	0.198	.024	15	view →
LUAD	OS	Median	III,IV	0.206	0.684	.002	7	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.824	.025	7	view →
HNSC	DFS	Quartile	II,III,IV	0.930	1.000	.041	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HYPK–PDAC (DFS)

Open the PDAC breakdown →